PROGRESSION / VERIFIED GUIDE
Pathogenic Plasmids Guide: Permanent Upgrades
Spend fragments and understand what persists.
Plasmid fragments fuel permanent progression between runs, with separate choices tied to Pathogens. Prioritize upgrades that make early runs consistent before chasing narrow bonuses; recommendations are strategy, not fixed facts.
Explain fragment sources, character trees, prerequisites, and first-upgrade principles with fact/opinion labels.
What Plasmids keep
Start with the exact player question behind “Pathogenic plasmids guide.” This section keeps the answer scannable, defines the terms that matter, and avoids padding the page with unrelated game information.
Facts are separated from strategy. Patch-sensitive mechanics carry a review date, and recommendations are presented as flexible options—not the only correct way to play.
Tree prerequisites
Use the system in context. Pathogenic rewards complete chains, so the practical advice here explains inputs, outputs, tradeoffs, and what to do when a run does not give you the ideal component.
First upgrades: principles, not a tier list
Finish with a decision you can use in the next run. Check the current version, follow the related mechanic or route page, and treat any community strategy as a tested option rather than a permanent rule.